Assay Detail
Binding
CHEMBL2329241
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Inhibition of human recombinant carbonic anhydrase 2 by dansylamide (DNSA) competition assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A multivalent approach towards linked dual-pharmacology prostaglandin F receptor agonist/carbonic anhydrase-II inhibitors for the treatment of glaucoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 8.21 | 9.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 9.90 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 9.70 |
| CHEMBL2325977 | — | — | 1 | 9.20 |
| CHEMBL2325981 | — | — | 1 | 8.90 |
| CHEMBL2325976 | — | — | 1 | 8.30 |
| CHEMBL2326219 | — | — | 1 | 8.10 |
| CHEMBL2326218 | — | — | 1 | 8.10 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.10 |
| CHEMBL2325978 | — | — | 1 | 7.40 |
| CHEMBL2325975 | — | — | 1 | 7.40 |
| CHEMBL2326217 | — | — | 1 | 7.30 |
| CHEMBL2325980 | — | — | 1 | 7.30 |
| CHEMBL2325979 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 0.1259 | nM | 9.90 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 0.1995 | nM | 9.70 |
| CHEMBL2325977 | — | Ki | = | 0.631 | nM | 9.20 |
| CHEMBL2325981 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL2325976 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL2326219 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL2326218 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL2325978 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL2325975 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL2326217 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL2325980 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL2325979 | — | Ki | = | 100.0 | nM | 7.00 |