Assay Detail
Binding
CHEMBL2329355
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Inhibition of Plasmodium falciparum recombinant DXR using DXP as substrate preincubated for 5 mins
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Antimalarial and Structural Studies of Pyridine-containing Inhibitors of 1-Deoxyxylulose-5-phosphate Reductoisomerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.66 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2323930 | — | — | 1 | 8.72 |
| CHEMBL2323929 | — | — | 1 | 8.05 |
| CHEMBL2323931 | — | — | 1 | 7.89 |
| CHEMBL2323928 | — | — | 1 | 7.89 |
| CHEMBL203125 | FOSMIDOMYCIN | 3.0 | 1 | 7.68 |
| CHEMBL205052 | — | — | 1 | 7.07 |
| CHEMBL2323932 | — | — | 1 | 6.32 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2323930 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL2323929 | — | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL2323931 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL2323928 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL203125 | FOSMIDOMYCIN | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL205052 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL2323932 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL76 | CHLOROQUINE | Ki | - | — | - |