Assay Detail
Binding
CHEMBL2329360
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of Clostridium botulinum truncated BoNT/A light chain (1-425) using truncated SNAP 25 (141-206) peptide as substrate by LC/MS analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Clostridium botulinum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Botulinum neurotoxin type A (CHEMBL5192) ↗| Type | SINGLE PROTEIN |
| Organism | Clostridium botulinum |
Publication
The C-terminus of Botulinum A Protease Has Profound and Unanticipated Kinetic Consequences Upon the Catalytic Cleft.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.62 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL237370 | CINNAMIC ACID HYDROXAMATE | — | 1 | 6.52 |
| CHEMBL29660 | CHICORIC ACID | — | 1 | 5.17 |
| CHEMBL1505471 | LOMOFUNGIN | -1.0 | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL237370 | CINNAMIC ACID HYDROXAMATE | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL29660 | CHICORIC ACID | Ki | = | 6700.0 | nM | 5.17 |
| CHEMBL1505471 | LOMOFUNGIN | Ki | = | 6700.0 | nM | 5.17 |