Assay Detail
Binding
CHEMBL2329434
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CA2 Ala65Ser and Asn67Gln double mutant expressed in Escherichia coli strain BL21 (DE3) after 6 hrs by stopped-flow CO2 hydration method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Sulfocoumarins (1,2-benzoxathiine-2,2-dioxides): a class of potent and isoform-selective inhibitors of tumor-associated carbonic anhydrases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.86 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2326506 | — | — | 1 | 6.10 |
| CHEMBL2326510 | — | — | 1 | 6.03 |
| CHEMBL2326507 | — | — | 1 | 5.69 |
| CHEMBL2326508 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2326506 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL2326510 | — | Ki | = | 930.0 | nM | 6.03 |
| CHEMBL2326507 | — | Ki | = | 2030.0 | nM | 5.69 |
| CHEMBL2326508 | — | Ki | = | 2370.0 | nM | 5.62 |