Assay Detail
Binding
CHEMBL2329436
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Inhibition of human recombinant transmembrane CA9 catalytic domain after 6 hrs by stopped-flow CO2 hydration method
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Sulfocoumarins (1,2-benzoxathiine-2,2-dioxides): a class of potent and isoform-selective inhibitors of tumor-associated carbonic anhydrases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 6.67 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2326520 | — | — | 1 | 7.75 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL2326518 | — | — | 1 | 7.60 |
| CHEMBL2326513 | — | — | 1 | 7.54 |
| CHEMBL2326511 | — | — | 1 | 7.34 |
| CHEMBL2326521 | — | — | 1 | 7.32 |
| CHEMBL2326522 | — | — | 1 | 7.31 |
| CHEMBL2326517 | — | — | 1 | 7.24 |
| CHEMBL2326516 | — | — | 1 | 7.22 |
| CHEMBL2326519 | — | — | 1 | 7.13 |
| CHEMBL2326515 | — | — | 1 | 7.07 |
| CHEMBL2326508 | — | — | 1 | 6.56 |
| CHEMBL2326506 | — | — | 1 | 6.52 |
| CHEMBL2326507 | — | — | 1 | 6.49 |
| CHEMBL2326509 | — | — | 1 | 6.43 |
| CHEMBL2326514 | — | — | 1 | 6.02 |
| CHEMBL2326512 | — | — | 1 | 5.49 |
| CHEMBL2321923 | — | — | 1 | 5.42 |
| CHEMBL2326510 | — | — | 1 | 5.17 |
| CHEMBL572366 | — | — | 1 | 4.26 |
| CHEMBL6466 | COUMARIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2326520 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL2326518 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL2326513 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL2326511 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL2326521 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL2326522 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL2326517 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL2326516 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL2326519 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL2326515 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL2326508 | — | Ki | = | 275.0 | nM | 6.56 |
| CHEMBL2326506 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL2326507 | — | Ki | = | 324.0 | nM | 6.49 |
| CHEMBL2326509 | — | Ki | = | 375.0 | nM | 6.43 |
| CHEMBL2326514 | — | Ki | = | 950.0 | nM | 6.02 |
| CHEMBL2326512 | — | Ki | = | 3260.0 | nM | 5.49 |
| CHEMBL2321923 | — | Ki | = | 3770.0 | nM | 5.42 |
| CHEMBL2326510 | — | Ki | = | 6830.0 | nM | 5.17 |
| CHEMBL572366 | — | Ki | = | 54500.0 | nM | 4.26 |
| CHEMBL6466 | COUMARIN | Ki | > | 100000.0 | nM | - |