Assay Detail
Binding
CHEMBL2329655
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Inhibition of rat SGLT1
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and structure-activity relationships of a series of 4-benzyl-5-isopropyl-1H-pyrazol-3-yl β-D-glycopyranosides substituted with novel hydrophilic groups as highly potent inhibitors of sodium glucose co-transporter 1 (SGLT1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.13 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2323695 | — | — | 1 | 7.66 |
| CHEMBL2323694 | — | — | 1 | 6.98 |
| CHEMBL2159101 | — | — | 1 | 6.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2323695 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2323694 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL2159101 | — | IC50 | = | 183.0 | nM | 6.74 |