Assay Detail
ADMET
CHEMBL2329692
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Cytotoxicity against human HepG2 cells after 72 hrs by Cell Titre Glo assay
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of chloronitrobenzamides (CNBs) as therapeutic leads for human African trypanosomiasis (HAT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 49 | 5.03 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2324283 | — | — | 1 | 5.28 |
| CHEMBL2324281 | — | — | 1 | 5.07 |
| CHEMBL2325788 | — | — | 1 | 4.75 |
| CHEMBL2324292 | — | — | 1 | - |
| CHEMBL2324293 | — | — | 1 | - |
| CHEMBL2324294 | — | — | 1 | - |
| CHEMBL2324282 | — | — | 1 | - |
| CHEMBL2325781 | — | — | 1 | - |
| CHEMBL2322969 | — | — | 1 | - |
| CHEMBL2325802 | — | — | 1 | - |
| CHEMBL2325803 | — | — | 1 | - |
| CHEMBL2325804 | — | — | 1 | - |
| CHEMBL2322968 | — | — | 1 | - |
| CHEMBL2322970 | — | — | 1 | - |
| CHEMBL2322971 | — | — | 1 | - |
| CHEMBL2322972 | — | — | 1 | - |
| CHEMBL2322973 | — | — | 1 | - |
| CHEMBL2322974 | — | — | 1 | - |
| CHEMBL2322975 | — | — | 1 | - |
| CHEMBL2322976 | — | — | 1 | - |
| CHEMBL2322977 | — | — | 1 | - |
| CHEMBL2322978 | — | — | 1 | - |
| CHEMBL591552 | — | — | 1 | - |
| CHEMBL2325786 | — | — | 1 | - |
| CHEMBL2325787 | — | — | 1 | - |
| CHEMBL2325789 | — | — | 1 | - |
| CHEMBL2325790 | — | — | 1 | - |
| CHEMBL2325791 | — | — | 1 | - |
| CHEMBL2325801 | — | — | 1 | - |
| CHEMBL2325792 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2324283 | — | EC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL2324281 | — | EC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL2325788 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL2324282 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL2325794 | — | EC50 | > | 27000.0 | nM | - |
| CHEMBL2324294 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL2324293 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL2324292 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL2324291 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL2324290 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL2324289 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL2324288 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL2324287 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL2324286 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL2324285 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL2324284 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL2325793 | — | EC50 | > | 27000.0 | nM | - |
| CHEMBL2324280 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL2325221 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL2322979 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL2325800 | — | EC50 | > | 27000.0 | nM | - |
| CHEMBL2325799 | — | EC50 | > | 27000.0 | nM | - |
| CHEMBL2325798 | — | EC50 | > | 27000.0 | nM | - |
| CHEMBL2325797 | — | EC50 | > | 27000.0 | nM | - |
| CHEMBL2325796 | — | EC50 | > | 27000.0 | nM | - |
| CHEMBL2325795 | — | EC50 | > | 27000.0 | nM | - |
| CHEMBL2322975 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL2325792 | — | EC50 | > | 27000.0 | nM | - |
| CHEMBL2325801 | — | EC50 | > | 14000.0 | nM | - |
| CHEMBL2325791 | — | EC50 | > | 27000.0 | nM | - |
| CHEMBL2325790 | — | EC50 | > | 27000.0 | nM | - |
| CHEMBL2325789 | — | EC50 | > | 27000.0 | nM | - |
| CHEMBL2325787 | — | EC50 | > | 27000.0 | nM | - |
| CHEMBL2325786 | — | EC50 | > | 27000.0 | nM | - |
| CHEMBL591552 | — | EC50 | > | 27000.0 | nM | - |
| CHEMBL2322978 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL2322977 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL2322976 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL2325781 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL2322974 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL2322973 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL2322972 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL2322971 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL2322970 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL2322968 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL2325804 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL2325803 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL2325802 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL2322969 | — | EC50 | > | 14000.0 | nM | - |