Assay Detail
Binding
CHEMBL2329908
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Inhibition of vasopressin-stimulated vasopressin V2 receptor in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay
8
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HTLA |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Colloidal aggregation causes inhibition of G protein-coupled receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.82 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2324200 | Tetra-iodophenolphthalein | — | 2 | 6.40 |
| CHEMBL64391 | ITRACONAZOLE | 4.0 | 2 | 6.10 |
| CHEMBL104 | CLOTRIMAZOLE | 4.0 | 2 | 5.60 |
| CHEMBL50 | QUERCETIN | 3.0 | 2 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2324200 | Tetra-iodophenolphthalein | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2324200 | Tetra-iodophenolphthalein | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL64391 | ITRACONAZOLE | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL64391 | ITRACONAZOLE | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL104 | CLOTRIMAZOLE | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL104 | CLOTRIMAZOLE | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL50 | QUERCETIN | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL50 | QUERCETIN | IC50 | = | 7000.0 | nM | 5.16 |