Assay Detail
Binding
CHEMBL2329915
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human His-tagged Frataxin/GST-tagged mono ubiquitin interaction expressed in human Calu6 cells after 3 days by GST pull down-based Western blot analysis
26
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Calu-6 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of a novel small molecule inhibitor targeting the frataxin/ubiquitin interaction via structure-based virtual screening and bioassays.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 13 | - | - |
| IC50 | 13 | 4.25 | 4.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1565145 | — | — | 2 | 4.70 |
| CHEMBL1476047 | — | — | 2 | 4.54 |
| CHEMBL1597349 | — | — | 2 | 4.36 |
| CHEMBL1436701 | — | — | 2 | 4.35 |
| CHEMBL1360494 | — | — | 2 | 4.28 |
| CHEMBL1319324 | — | — | 2 | 4.19 |
| CHEMBL2323557 | — | — | 2 | 4.17 |
| CHEMBL1369923 | — | — | 2 | 4.17 |
| CHEMBL1434181 | — | — | 2 | 4.16 |
| CHEMBL1360077 | — | — | 2 | 4.10 |
| CHEMBL1490147 | — | — | 2 | 4.09 |
| CHEMBL1551957 | — | — | 2 | 4.09 |
| CHEMBL1450405 | — | — | 2 | 4.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1565145 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL1476047 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL1597349 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL1436701 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL1360494 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL1319324 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL1369923 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL2323557 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL1434181 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL1360077 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL1490147 | — | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL1551957 | — | IC50 | = | 81000.0 | nM | 4.09 |
| CHEMBL1450405 | — | IC50 | = | 97000.0 | nM | 4.01 |
| CHEMBL1360077 | — | Inhibition | - | % | - | |
| CHEMBL1476047 | — | Inhibition | - | % | - | |
| CHEMBL1597349 | — | Inhibition | - | % | - | |
| CHEMBL1360494 | — | Inhibition | - | % | - | |
| CHEMBL1565145 | — | Inhibition | - | % | - | |
| CHEMBL1319324 | — | Inhibition | - | % | - | |
| CHEMBL2323557 | — | Inhibition | - | % | - | |
| CHEMBL1551957 | — | Inhibition | - | % | - | |
| CHEMBL1490147 | — | Inhibition | - | % | - | |
| CHEMBL1450405 | — | Inhibition | - | % | - | |
| CHEMBL1434181 | — | Inhibition | - | % | - | |
| CHEMBL1369923 | — | Inhibition | - | % | - | |
| CHEMBL1436701 | — | Inhibition | - | % | - |