Assay Detail
Functional
CHEMBL2329982
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Antimalarial activity against wild type early trophozoite stage of Plasmodium falciparum D6 in human red blood cells assessed as [3H]hypoxanthine uptake after 96 hrs
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.30 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.77 |
| CHEMBL2325750 | — | — | 1 | 5.42 |
| CHEMBL2325751 | — | — | 1 | 5.18 |
| CHEMBL2063188 | — | — | 1 | 5.12 |
| CHEMBL2325749 | — | — | 1 | 5.01 |
| CHEMBL2325756 | — | — | 1 | 4.38 |
| CHEMBL2063186 | — | — | 1 | 4.23 |
| CHEMBL1229838 | — | — | 1 | - |
| CHEMBL2325752 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2325750 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL2325751 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL2063188 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL2325749 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL2325756 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL2063186 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL1229838 | — | IC50 | = | 242000.0 | nM | - |
| CHEMBL2325752 | — | IC50 | - | — | - |