Assay Detail
Binding
CHEMBL2330000
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Binding affinity to BCL2 (unknown origin) after 2 hrs by fluorescence polarization assay
29
Total Activities
28
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A potent and highly efficacious Bcl-2/Bcl-xL inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.95 | 9.05 |
| Ki | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2325766 | — | — | 1 | 9.05 |
| CHEMBL2325770 | — | — | 1 | 8.96 |
| CHEMBL2159737 | — | — | 1 | 8.89 |
| CHEMBL2159740 | — | — | 1 | 8.85 |
| CHEMBL2325771 | — | — | 1 | 8.82 |
| CHEMBL2325763 | — | — | 1 | 8.74 |
| CHEMBL2325764 | — | — | 2 | 8.74 |
| CHEMBL2159739 | — | — | 1 | 8.70 |
| CHEMBL2325759 | — | — | 1 | 8.43 |
| CHEMBL2326039 | — | — | 1 | 8.42 |
| CHEMBL2325760 | — | — | 1 | 8.42 |
| CHEMBL2159736 | — | — | 1 | 8.30 |
| CHEMBL2325757 | — | — | 1 | 8.27 |
| CHEMBL2325765 | — | — | 1 | 8.25 |
| CHEMBL2325758 | — | — | 1 | 8.15 |
| CHEMBL2326041 | — | — | 1 | 8.12 |
| CHEMBL2325761 | — | — | 1 | 8.00 |
| CHEMBL2325769 | — | — | 1 | 7.77 |
| CHEMBL2326040 | — | — | 1 | 7.72 |
| CHEMBL2325762 | — | — | 1 | 7.64 |
| CHEMBL2325772 | — | — | 1 | 7.34 |
| CHEMBL2159738 | — | — | 1 | 7.00 |
| CHEMBL2325773 | — | — | 1 | 6.96 |
| CHEMBL2326037 | — | — | 1 | 6.85 |
| CHEMBL2325774 | — | — | 1 | 6.68 |
| CHEMBL2325767 | — | — | 1 | 6.58 |
| CHEMBL2325768 | — | — | 1 | 6.57 |
| CHEMBL2326038 | — | — | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2325766 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL2325770 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL2159737 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL2159740 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL2325771 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL2325764 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL2325763 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL2159739 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2325759 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL2326039 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL2325760 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL2159736 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2325757 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL2325765 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL2325758 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL2326041 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL2325761 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2325769 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2326040 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2325762 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL2325772 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL2159738 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL2325773 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2326037 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2325774 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL2325767 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL2325768 | — | IC50 | = | 271.0 | nM | 6.57 |
| CHEMBL2326038 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL2325764 | — | Ki | < | 1.0 | nM | - |