Assay Detail
Binding
CHEMBL2330092
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Inhibition of Abl2 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 mins
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rapid discovery of a novel series of Abl kinase inhibitors by application of an integrated microfluidic synthesis and screening platform.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.82 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2324924 | — | — | 1 | 9.00 |
| CHEMBL2324926 | — | — | 1 | 8.22 |
| CHEMBL2324930 | — | — | 1 | 8.10 |
| CHEMBL2324925 | — | — | 1 | 8.00 |
| CHEMBL2324927 | — | — | 1 | 7.92 |
| CHEMBL2324928 | — | — | 1 | 7.85 |
| CHEMBL2324923 | — | — | 1 | 7.82 |
| CHEMBL2324931 | — | — | 1 | 7.75 |
| CHEMBL2324929 | — | — | 1 | 7.44 |
| CHEMBL2324932 | — | — | 1 | 7.40 |
| CHEMBL2321908 | — | — | 1 | 6.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2324924 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2324926 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2324930 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2324925 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2324927 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2324928 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2324923 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2324931 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2324929 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL2324932 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2321908 | — | IC50 | = | 298.0 | nM | 6.53 |