Assay Detail
Binding
CHEMBL2330132
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at ERalpha receptor in human MCF7 cells assessed as inhibition of cell growth after 6 days by crystal violet staining method
10
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of novel estrogen receptor antagonists using metal-catalyzed coupling reactions and characterization of their biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.38 | 8.70 |
| Inhibition | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1358 | FULVESTRANT | 4.0 | 1 | 8.70 |
| CHEMBL2326068 | — | — | 2 | 7.30 |
| CHEMBL2326075 | — | — | 2 | 7.30 |
| CHEMBL2326074 | — | — | 2 | 7.30 |
| CHEMBL2326070 | — | — | 2 | 7.00 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1358 | FULVESTRANT | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2326068 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2326075 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2326074 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2326070 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL83 | TAMOXIFEN | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2326068 | — | Inhibition | - | % | - | |
| CHEMBL2326070 | — | Inhibition | - | % | - | |
| CHEMBL2326075 | — | Inhibition | - | % | - | |
| CHEMBL2326074 | — | Inhibition | - | % | - |