Assay Detail
Binding
CHEMBL2330147
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Trypanosoma brucei full length PDEB1 expressed in insect SF21 cells using cAMP as substrate by scintillation proximity assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma brucei |
| Cell Type | Sf21 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Class 1 phosphodiesterase PDEB1 (CHEMBL2010636) ↗| Type | SINGLE PROTEIN |
| Organism | Trypanosoma brucei |
Publication
Discovery of novel Trypanosoma brucei phosphodiesterase B1 inhibitors by virtual screening against the unliganded TbrPDEB1 crystal structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.14 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2326941 | — | — | 1 | 8.40 |
| CHEMBL2326942 | — | — | 1 | 5.00 |
| CHEMBL2326943 | — | — | 1 | 4.92 |
| CHEMBL1382213 | — | — | 1 | 4.89 |
| CHEMBL2326944 | — | — | 1 | 4.39 |
| CHEMBL2326945 | — | — | 1 | 4.27 |
| CHEMBL2326946 | — | — | 1 | 4.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2326941 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2326942 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2326943 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1382213 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL2326944 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL2326945 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL2326946 | — | IC50 | = | 75000.0 | nM | 4.12 |