Assay Detail
Functional
CHEMBL2330468
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Cytotoxicity against human MIAPaCa2 cells after 96 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MIA PaCa-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
GC-targeted C8-linked pyrrolobenzodiazepine-biaryl conjugates with femtomolar in vitro cytotoxicity and in vivo antitumor activity in mouse models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.92 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2324627 | — | — | 1 | 9.96 |
| CHEMBL2324629 | — | — | 1 | 9.60 |
| CHEMBL2324628 | — | — | 1 | 9.51 |
| CHEMBL2324626 | — | — | 1 | 9.47 |
| CHEMBL2324625 | — | — | 1 | 9.46 |
| CHEMBL2324624 | — | — | 1 | 8.92 |
| CHEMBL215032 | — | — | 1 | 8.62 |
| CHEMBL2324631 | — | — | 1 | 5.81 |
| CHEMBL2324632 | — | — | 1 | - |
| CHEMBL1993268 | — | — | 1 | - |
| CHEMBL2324630 | — | — | 1 | - |
| CHEMBL2321905 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2324627 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL2324629 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL2324628 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL2324626 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL2324625 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL2324624 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL215032 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL2324631 | — | IC50 | = | 1564.0 | nM | 5.81 |
| CHEMBL2324632 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1993268 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2324630 | — | IC50 | = | 0.0021 | nM | - |
| CHEMBL2321905 | — | IC50 | = | 0.0013 | nM | - |