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Assay Detail

CHEMBL2330479

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Functional
Antiparasitic activity against wild type tachyzoites of Toxoplasma gondii RH type 1 infected in HFF cells incubated for 20 mins prior to inoculation followed by compound washout at 4 hrs measured after 72 hrs by beta-galactoside reporter assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Toxoplasma gondii
Cell Type HFF
Confidence 1 — Organism
Curated By Autocuration

Target

Toxoplasma gondii (CHEMBL612888)
Type ORGANISM
Organism Toxoplasma gondii

Publication

Optimizing small molecule inhibitors of calcium-dependent protein kinase 1 to prevent infection by Toxoplasma gondii.
Lourido S, Zhang C, Lopez MS, Tang K, Barks J, Wang Q, Wildman SA, Shokat KM, Sibley LD.
J Med Chem (2013) 56 : 3068 -3077
PubMed 23470217 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 26 6.04 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2324597 1 7.52
CHEMBL1236661 1 6.96
CHEMBL2324590 1 6.75
CHEMBL2324602 1 6.60
CHEMBL2324609 1 6.44
CHEMBL1232415 1 6.42
CHEMBL2324603 1 6.42
CHEMBL2324589 1 6.39
CHEMBL2324591 1 6.37
CHEMBL2323835 1 6.25
CHEMBL2324593 1 6.21
CHEMBL2324605 1 6.21
CHEMBL264406 1 6.16
CHEMBL2324601 1 6.04
CHEMBL1254115 1 5.95
CHEMBL573578 1 5.88
CHEMBL2324599 1 5.88
CHEMBL2324608 1 5.85
CHEMBL2324598 1 5.71
CHEMBL2324592 1 5.68
CHEMBL2324595 1 5.58
CHEMBL2324604 1 5.42
CHEMBL2324606 1 5.34
CHEMBL2324600 1 5.17
CHEMBL2324594 1 5.02
CHEMBL2324607 1 4.94

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2324597 EC50 = 30.0 nM 7.52
CHEMBL1236661 EC50 = 110.0 nM 6.96
CHEMBL2324590 EC50 = 180.0 nM 6.75
CHEMBL2324602 EC50 = 250.0 nM 6.60
CHEMBL2324609 EC50 = 360.0 nM 6.44
CHEMBL1232415 EC50 = 380.0 nM 6.42
CHEMBL2324603 EC50 = 380.0 nM 6.42
CHEMBL2324589 EC50 = 410.0 nM 6.39
CHEMBL2324591 EC50 = 430.0 nM 6.37
CHEMBL2323835 EC50 = 560.0 nM 6.25
CHEMBL2324593 EC50 = 610.0 nM 6.21
CHEMBL2324605 EC50 = 620.0 nM 6.21
CHEMBL264406 EC50 = 700.0 nM 6.16
CHEMBL2324601 EC50 = 920.0 nM 6.04
CHEMBL1254115 EC50 = 1120.0 nM 5.95
CHEMBL573578 EC50 = 1310.0 nM 5.88
CHEMBL2324599 EC50 = 1320.0 nM 5.88
CHEMBL2324608 EC50 = 1400.0 nM 5.85
CHEMBL2324598 EC50 = 1940.0 nM 5.71
CHEMBL2324592 EC50 = 2070.0 nM 5.68
CHEMBL2324595 EC50 = 2630.0 nM 5.58
CHEMBL2324604 EC50 = 3770.0 nM 5.42
CHEMBL2324606 EC50 = 4530.0 nM 5.34
CHEMBL2324600 EC50 = 6730.0 nM 5.17
CHEMBL2324594 EC50 = 9460.0 nM 5.02
CHEMBL2324607 EC50 = 11590.0 nM 4.94