Assay Detail
Binding
CHEMBL2330617
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mTOR (unknown origin)
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and cancer stem cell-based activity of substituted 5-morpholino-7H-thieno[3,2-b]pyran-7-ones designed as next generation PI3K inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.24 | 6.54 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2322228 | — | — | 1 | 6.54 |
| CHEMBL2322239 | — | — | 1 | 6.21 |
| CHEMBL98350 | LY-294002 | -1.0 | 1 | 5.97 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2322228 | — | IC50 | = | 289.0 | nM | 6.54 |
| CHEMBL2322239 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL98350 | LY-294002 | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL1879463 | DACTOLISIB | Inhibition | - | % | - |