Assay Detail
Binding
CHEMBL2330634
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant mTOR (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.80 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2325697 | — | — | 1 | 7.42 |
| CHEMBL2325704 | — | — | 1 | 6.75 |
| CHEMBL2325703 | — | — | 1 | 6.72 |
| CHEMBL2325706 | — | — | 1 | 6.64 |
| CHEMBL2030442 | — | — | 1 | 6.48 |
| CHEMBL2325705 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2325697 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL2325704 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2325703 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2325706 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL2030442 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL2325705 | — | IC50 | - | — | - |