Assay Detail
Binding
CHEMBL2330682
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]diprenorphine from human KOR expressed in CHO cells after 1 hr by liquid scintillation counting analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Opioid peptidomimetics: leads for the design of bioavailable mixed efficacy μ opioid receptor (MOR) agonist/δ opioid receptor (DOR) antagonist ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.24 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2322563 | — | — | 1 | 8.92 |
| CHEMBL2322561 | — | — | 1 | 7.77 |
| CHEMBL2322560 | — | — | 1 | 7.60 |
| CHEMBL2322562 | — | — | 1 | 7.27 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 7.21 |
| CHEMBL2322568 | — | — | 1 | 7.17 |
| CHEMBL2322567 | — | — | 1 | 6.96 |
| CHEMBL2322566 | — | — | 1 | 6.89 |
| CHEMBL2322564 | — | — | 1 | 6.66 |
| CHEMBL2322565 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2322563 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL2322561 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL2322560 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL2322562 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL70 | MORPHINE | Ki | = | 60.9 | nM | 7.21 |
| CHEMBL2322568 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL2322567 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL2322566 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL2322564 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL2322565 | — | Ki | = | 1200.0 | nM | 5.92 |