Assay Detail
Functional
CHEMBL2330685
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Agonist activity at human KOR expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Opioid peptidomimetics: leads for the design of bioavailable mixed efficacy μ opioid receptor (MOR) agonist/δ opioid receptor (DOR) antagonist ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.72 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2322563 | — | — | 1 | 7.17 |
| CHEMBL2322568 | — | — | 1 | 6.27 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | - |
| CHEMBL2322562 | — | — | 1 | - |
| CHEMBL2322561 | — | — | 1 | - |
| CHEMBL2322560 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2322563 | — | EC50 | = | 68.0 | nM | 7.17 |
| CHEMBL2322568 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL70 | MORPHINE | EC50 | - | — | - | |
| CHEMBL2322562 | — | EC50 | - | — | - | |
| CHEMBL2322561 | — | EC50 | - | — | - | |
| CHEMBL2322560 | — | EC50 | - | — | - |