Assay Detail
Binding
CHEMBL2330705
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Inhibition of human neuraminidase 2 expressed in Escherichia coli using 4MU-NANA as substrate after 30 mins by fluorescence assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of selective inhibitors for human neuraminidase isoenzymes using C4,C7-modified 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.18 | 4.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2325813 | — | — | 1 | 4.40 |
| CHEMBL52270 | — | — | 1 | 4.36 |
| CHEMBL2325808 | — | — | 1 | 4.23 |
| CHEMBL2323564 | — | — | 1 | 4.17 |
| CHEMBL2325810 | — | — | 1 | 4.13 |
| CHEMBL2323563 | — | — | 1 | 4.07 |
| CHEMBL96712 | NEU5AC2EN | — | 1 | 4.05 |
| CHEMBL2323562 | — | — | 1 | 4.00 |
| CHEMBL2323561 | — | — | 1 | - |
| CHEMBL2325812 | — | — | 1 | - |
| CHEMBL2325811 | — | — | 1 | - |
| CHEMBL2325809 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2325813 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL52270 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL2325808 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL2323564 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL2325810 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL2323563 | — | IC50 | = | 86000.0 | nM | 4.07 |
| CHEMBL96712 | NEU5AC2EN | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL2323562 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL2323561 | — | IC50 | = | 800000.0 | nM | - |
| CHEMBL2325812 | — | IC50 | = | 173000.0 | nM | - |
| CHEMBL2325811 | — | IC50 | = | 920000.0 | nM | - |
| CHEMBL2325809 | — | IC50 | = | 131000.0 | nM | - |