Assay Detail
Binding
CHEMBL2330714
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PARP1/PARP2 in human SKOV3 cells assessed as reduction in H2O2-induced PARylation incubated for 4 hrs prior to H2O2 treatment
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of a series of benzo[de][1,7]naphthyridin-7(8H)-ones bearing a functionalized longer chain appendage as novel PARP1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.06 | 9.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2323226 | — | — | 1 | 9.31 |
| CHEMBL521686 | OLAPARIB | 4.0 | 1 | 7.68 |
| CHEMBL2322618 | — | — | 1 | 7.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2323226 | — | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL521686 | OLAPARIB | IC50 | = | 20.9 | nM | 7.68 |
| CHEMBL2322618 | — | IC50 | = | 66.1 | nM | 7.18 |