Assay Detail
Functional
CHEMBL2330996
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei gambiense KO48 after 70 hrs by Alamar Blue assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei gambiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei gambiense (CHEMBL613768) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei gambiense |
Publication
Optimization of chloronitrobenzamides (CNBs) as therapeutic leads for human African trypanosomiasis (HAT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.56 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 7.85 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 7.29 |
| CHEMBL2325795 | — | — | 1 | 6.77 |
| CHEMBL2325781 | — | — | 1 | 6.34 |
| CHEMBL2325789 | — | — | 1 | 6.20 |
| CHEMBL2325786 | — | — | 1 | 5.89 |
| CHEMBL2324296 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL55 | PENTAMIDINE | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL2325795 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2325781 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL2325789 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL2325786 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2324296 | — | EC50 | = | 2600.0 | nM | 5.58 |