Assay Detail
Functional
CHEMBL2330998
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei gambiense STIB930 after 70 hrs by Alamar Blue assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei gambiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei gambiense (CHEMBL613768) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei gambiense |
Publication
Optimization of chloronitrobenzamides (CNBs) as therapeutic leads for human African trypanosomiasis (HAT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 7.29 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 9.15 |
| CHEMBL2325221 | — | — | 1 | 9.00 |
| CHEMBL2322979 | — | — | 1 | 8.70 |
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 8.17 |
| CHEMBL2322969 | — | — | 1 | 7.44 |
| CHEMBL2322976 | — | — | 1 | 7.20 |
| CHEMBL2322971 | — | — | 1 | 7.20 |
| CHEMBL2324282 | — | — | 1 | 7.14 |
| CHEMBL2325795 | — | — | 1 | 6.96 |
| CHEMBL2324281 | — | — | 1 | 6.80 |
| CHEMBL2324280 | — | — | 1 | 6.77 |
| CHEMBL2322975 | — | — | 1 | 6.70 |
| CHEMBL2325781 | — | — | 1 | 6.68 |
| CHEMBL2324296 | — | — | 1 | 6.38 |
| CHEMBL2325789 | — | — | 1 | 6.25 |
| CHEMBL2325786 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL2325221 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2322979 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL166 | MELARSOPROL | EC50 | = | 6.7 | nM | 8.17 |
| CHEMBL2322969 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL2322976 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL2322971 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL2324282 | — | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL2325795 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2324281 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2324280 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2322975 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2325781 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL2324296 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL2325789 | — | EC50 | = | 560.0 | nM | 6.25 |
| CHEMBL2325786 | — | EC50 | = | 820.0 | nM | 6.09 |