Assay Detail
Binding
CHEMBL2338832
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant FLAG-tagged mTOR (1362 to 2549) (unknown origin) expressed in HEK293 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: the discovery of AZD8055 and AZD2014.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.01 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 9.89 |
| CHEMBL1078983 | Ku-0063794 | — | 1 | 8.60 |
| CHEMBL2336325 | VISTUSERTIB | 2.0 | 1 | 8.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1801204 | AZD-8055 | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL1078983 | Ku-0063794 | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL2336325 | VISTUSERTIB | IC50 | = | 2.8 | nM | 8.55 |