Assay Detail
Binding
CHEMBL2338837
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant MMP2 using succinylated gelatin as substrate incubated for 30 mins prior to substrate addition measured after 60 mins
73
Total Activities
73
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationship analysis of caffeic acid amides as selective matrix metalloproteinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 73 | 7.50 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69803 | — | — | 1 | 8.48 |
| CHEMBL1163455 | — | — | 1 | 8.47 |
| CHEMBL1165106 | — | — | 1 | 8.45 |
| CHEMBL2336340 | — | — | 1 | 8.40 |
| CHEMBL2336343 | — | — | 1 | 8.39 |
| CHEMBL2336779 | — | — | 1 | 8.38 |
| CHEMBL2336346 | 4-METHYL-(4'-HYDROXY)CINNAMANILIDE | — | 1 | 8.38 |
| CHEMBL2336782 | — | — | 1 | 8.37 |
| CHEMBL2336785 | 4-METHYL-(3'-HYDROXY)CINNAMANILIDE | — | 1 | 8.35 |
| CHEMBL421295 | — | — | 1 | 8.29 |
| CHEMBL1165627 | — | — | 1 | 8.28 |
| CHEMBL229844 | — | — | 1 | 8.28 |
| CHEMBL2336357 | N-(4-METHOXYPHENYL)CINNAMAMIDE | — | 1 | 8.27 |
| CHEMBL2336359 | N-P-TOLYLCINNAMAMIDE | — | 1 | 8.26 |
| CHEMBL2336338 | — | — | 1 | 8.26 |
| CHEMBL2336341 | — | — | 1 | 8.26 |
| CHEMBL2336344 | — | — | 1 | 8.25 |
| CHEMBL2336365 | — | — | 1 | 8.25 |
| CHEMBL2336780 | — | — | 1 | 8.25 |
| CHEMBL2336783 | — | — | 1 | 8.24 |
| CHEMBL1165152 | — | — | 1 | 8.22 |
| CHEMBL2336353 | N-(2-HYDROXYPHENYL)CINNAMAMIDE | — | 1 | 8.21 |
| CHEMBL2336355 | N-(2-METHOXYPHENYL)CINNAMAMIDE | — | 1 | 8.20 |
| CHEMBL2336358 | N-O-TOLYLCINNAMAMIDE | — | 1 | 8.19 |
| CHEMBL67498 | CAFFEIC ACID PHENETHYL AMIDE | — | 1 | 8.09 |
| CHEMBL67291 | — | — | 1 | 8.09 |
| CHEMBL275362 | — | — | 1 | 8.09 |
| CHEMBL1163444 | — | — | 1 | 8.08 |
| CHEMBL2336337 | — | — | 1 | 8.08 |
| CHEMBL325749 | — | — | 1 | 8.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69803 | — | IC50 | = | 3.28 | nM | 8.48 |
| CHEMBL1163455 | — | IC50 | = | 3.42 | nM | 8.47 |
| CHEMBL1165106 | — | IC50 | = | 3.55 | nM | 8.45 |
| CHEMBL2336340 | — | IC50 | = | 3.97 | nM | 8.40 |
| CHEMBL2336343 | — | IC50 | = | 4.09 | nM | 8.39 |
| CHEMBL2336779 | — | IC50 | = | 4.18 | nM | 8.38 |
| CHEMBL2336346 | 4-METHYL-(4'-HYDROXY)CINNAMANILIDE | IC50 | = | 4.19 | nM | 8.38 |
| CHEMBL2336782 | — | IC50 | = | 4.32 | nM | 8.37 |
| CHEMBL2336785 | 4-METHYL-(3'-HYDROXY)CINNAMANILIDE | IC50 | = | 4.43 | nM | 8.35 |
| CHEMBL421295 | — | IC50 | = | 5.09 | nM | 8.29 |
| CHEMBL1165627 | — | IC50 | = | 5.27 | nM | 8.28 |
| CHEMBL229844 | — | IC50 | = | 5.28 | nM | 8.28 |
| CHEMBL2336357 | N-(4-METHOXYPHENYL)CINNAMAMIDE | IC50 | = | 5.37 | nM | 8.27 |
| CHEMBL2336338 | — | IC50 | = | 5.47 | nM | 8.26 |
| CHEMBL2336359 | N-P-TOLYLCINNAMAMIDE | IC50 | = | 5.46 | nM | 8.26 |
| CHEMBL2336341 | — | IC50 | = | 5.53 | nM | 8.26 |
| CHEMBL2336344 | — | IC50 | = | 5.62 | nM | 8.25 |
| CHEMBL2336365 | — | IC50 | = | 5.57 | nM | 8.25 |
| CHEMBL2336780 | — | IC50 | = | 5.62 | nM | 8.25 |
| CHEMBL2336783 | — | IC50 | = | 5.73 | nM | 8.24 |
| CHEMBL1165152 | — | IC50 | = | 5.97 | nM | 8.22 |
| CHEMBL2336353 | N-(2-HYDROXYPHENYL)CINNAMAMIDE | IC50 | = | 6.24 | nM | 8.21 |
| CHEMBL2336355 | N-(2-METHOXYPHENYL)CINNAMAMIDE | IC50 | = | 6.32 | nM | 8.20 |
| CHEMBL2336358 | N-O-TOLYLCINNAMAMIDE | IC50 | = | 6.41 | nM | 8.19 |
| CHEMBL275362 | — | IC50 | = | 8.05 | nM | 8.09 |
| CHEMBL67291 | — | IC50 | = | 8.22 | nM | 8.09 |
| CHEMBL67498 | CAFFEIC ACID PHENETHYL AMIDE | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL1163444 | — | IC50 | = | 8.31 | nM | 8.08 |
| CHEMBL2336337 | — | IC50 | = | 8.32 | nM | 8.08 |
| CHEMBL325749 | — | IC50 | = | 8.37 | nM | 8.08 |
| CHEMBL1164826 | 4-HYDROXY-CINNAMANILIDE | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL2336349 | — | IC50 | = | 8.39 | nM | 8.08 |
| CHEMBL2336364 | — | IC50 | = | 8.46 | nM | 8.07 |
| CHEMBL2336363 | — | IC50 | = | 8.44 | nM | 8.07 |
| CHEMBL2336362 | 3-HYDROXY-CINNAMANILIDE | IC50 | = | 8.41 | nM | 8.07 |
| CHEMBL2336788 | — | IC50 | = | 8.59 | nM | 8.07 |
| CHEMBL1165150 | — | IC50 | = | 8.95 | nM | 8.05 |
| CHEMBL1165574 | — | IC50 | = | 8.92 | nM | 8.05 |
| CHEMBL1830129 | N-PHENYLCINNAMAMIDE | IC50 | = | 8.95 | nM | 8.05 |
| CHEMBL2336352 | N-BENZYLCINNAMAMIDE | IC50 | = | 9.02 | nM | 8.04 |
| CHEMBL2336351 | — | IC50 | = | 9.04 | nM | 8.04 |
| CHEMBL2336786 | — | IC50 | = | 9.09 | nM | 8.04 |
| CHEMBL1163867 | — | IC50 | = | 9.11 | nM | 8.04 |
| CHEMBL2336336 | — | IC50 | = | 9.11 | nM | 8.04 |
| CHEMBL1305393 | — | IC50 | = | 9.13 | nM | 8.04 |
| CHEMBL2336347 | — | IC50 | = | 9.01 | nM | 8.04 |
| CHEMBL2336361 | N-(4-FLUOROPHENYL)CINNAMAMIDE | IC50 | = | 9.17 | nM | 8.04 |
| CHEMBL2336789 | — | IC50 | = | 9.41 | nM | 8.03 |
| CHEMBL2336350 | — | IC50 | = | 9.26 | nM | 8.03 |
| CHEMBL1998736 | N-(2-FLUOROPHENYL)CINNAMAMIDE | IC50 | = | 9.66 | nM | 8.02 |