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Assay Detail

CHEMBL2338995

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of fibronectin binding to human Integrin alpha5beta1 receptor by competitive ELISA
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 7 — Homologous single protein target
Curated By Autocuration

Target

Integrin alpha-5/beta-1 (CHEMBL2095226)
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

Biselectivity of isoDGR peptides for fibronectin binding integrin subtypes α5β1 and αvβ6: conformational control through flanking amino acids.
Bochen A, Marelli UK, Otto E, Pallarola D, Mas-Moruno C, Di Leva FS, Boehm H, Spatz JP, Novellino E, Kessler H, Marinelli L.
J Med Chem (2013) 56 : 1509 -1519
PubMed 23362923 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 7.41 8.26

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2332827 1 8.26
CHEMBL2332835 1 8.15
CHEMBL2332837 1 8.14
CHEMBL2332833 1 8.06
CHEMBL2332829 1 8.06
CHEMBL2332832 1 7.96
CHEMBL429876 CILENGITIDE 3.0 1 7.82
CHEMBL2332839 1 7.72
CHEMBL2332371 1 7.57
CHEMBL2332830 1 7.41
CHEMBL2332828 1 7.14
CHEMBL2332831 1 7.04
CHEMBL2332834 1 7.03
CHEMBL2332836 1 6.96
CHEMBL2332838 1 6.94
CHEMBL2332367 1 6.88
CHEMBL2332370 1 6.71
CHEMBL2332368 1 5.55

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2332827 IC50 = 5.5 nM 8.26
CHEMBL2332835 IC50 = 7.0 nM 8.15
CHEMBL2332837 IC50 = 7.3 nM 8.14
CHEMBL2332833 IC50 = 8.7 nM 8.06
CHEMBL2332829 IC50 = 8.7 nM 8.06
CHEMBL2332832 IC50 = 11.0 nM 7.96
CHEMBL429876 CILENGITIDE IC50 = 15.0 nM 7.82
CHEMBL2332839 IC50 = 19.0 nM 7.72
CHEMBL2332371 IC50 = 27.0 nM 7.57
CHEMBL2332830 IC50 = 39.0 nM 7.41
CHEMBL2332828 IC50 = 72.0 nM 7.14
CHEMBL2332831 IC50 = 92.0 nM 7.04
CHEMBL2332834 IC50 = 94.0 nM 7.03
CHEMBL2332836 IC50 = 111.0 nM 6.96
CHEMBL2332838 IC50 = 115.0 nM 6.94
CHEMBL2332367 IC50 = 133.0 nM 6.88
CHEMBL2332370 IC50 = 197.0 nM 6.71
CHEMBL2332368 IC50 = 2807.0 nM 5.55