Assay Detail
Functional
CHEMBL2339446
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Cytotoxicity against human MCF7 cells assessed as growth inhibition after 96 hrs by SRB assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-based design and evaluation of naphthalene diimide G-quadruplex ligands as telomere targeting agents in pancreatic cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.41 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2335142 | — | — | 1 | 7.52 |
| CHEMBL2335138 | — | — | 1 | 7.16 |
| CHEMBL1269245 | — | — | 1 | 6.77 |
| CHEMBL2335140 | — | — | 1 | 6.77 |
| CHEMBL2335141 | — | — | 1 | 6.75 |
| CHEMBL2335136 | — | — | 1 | 5.58 |
| CHEMBL2335137 | — | — | 1 | 5.51 |
| CHEMBL2335139 | — | — | 1 | 5.25 |
| CHEMBL2335135 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2335142 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2335138 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1269245 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2335140 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2335141 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2335136 | — | IC50 | = | 2610.0 | nM | 5.58 |
| CHEMBL2335137 | — | IC50 | = | 3120.0 | nM | 5.51 |
| CHEMBL2335139 | — | IC50 | = | 5620.0 | nM | 5.25 |
| CHEMBL2335135 | — | IC50 | > | 10000.0 | nM | - |