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Assay Detail

CHEMBL2339489

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Binding
Inhibition of MMP13 (unknown origin)
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Collagenase 3 (CHEMBL280)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Sulphonamides: Deserving class as MMP inhibitors?
Jain P, Saravanan C, Singh SK.
Eur J Med Chem (2013) 60 : 89 -100
PubMed 23287054 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 8.11 10.21

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL330028 1 10.21
CHEMBL114815 1 9.19
CHEMBL319341 1 9.10
CHEMBL2337129 1 8.89
CHEMBL311932 1 8.52
CHEMBL43152 1 8.10
CHEMBL2337130 1 7.91
CHEMBL83209 1 7.55
CHEMBL310008 1 7.48
CHEMBL421699 1 7.33
CHEMBL81113 1 6.63
CHEMBL78826 1 6.37
CHEMBL421882 1 -
CHEMBL147489 1 -
CHEMBL226439 1 -
CHEMBL181244 1 -
CHEMBL2337131 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL330028 IC50 = 0.062 nM 10.21
CHEMBL114815 IC50 = 0.65 nM 9.19
CHEMBL319341 IC50 = 0.8 nM 9.10
CHEMBL2337129 IC50 = 1.3 nM 8.89
CHEMBL311932 IC50 = 3.0 nM 8.52
CHEMBL43152 IC50 = 8.0 nM 8.10
CHEMBL2337130 IC50 = 12.2 nM 7.91
CHEMBL83209 IC50 = 28.0 nM 7.55
CHEMBL310008 IC50 = 33.0 nM 7.48
CHEMBL421699 IC50 = 47.0 nM 7.33
CHEMBL81113 IC50 = 233.0 nM 6.63
CHEMBL78826 IC50 = 427.0 nM 6.37
CHEMBL421882 IC50 = 0.008 nM -
CHEMBL147489 IC50 - -
CHEMBL226439 IC50 - -
CHEMBL181244 IC50 - -
CHEMBL2337131 IC50 - -