Assay Detail
Binding
CHEMBL2339937
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Staphylococcus aureus Newman His6-tagged MgrA expressed in Escherichia coli BL21(DE3) using 5'-6-F-TAAACAACAAGTTGTCCAAA-3' as substrate after 20 mins by fluorescence anisotropic analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
HTH-type transcriptional regulator MgrA (CHEMBL2331056) ↗| Type | SINGLE PROTEIN |
| Organism | Staphylococcus aureus |
Publication
Attenuating Staphylococcus aureus virulence gene regulation: a medicinal chemistry perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.67 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL115145 | — | — | 1 | 5.10 |
| CHEMBL2337552 | — | — | 1 | 4.55 |
| CHEMBL2337551 | — | — | 1 | 4.52 |
| CHEMBL2337553 | — | — | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL115145 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL2337552 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL2337551 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL2337553 | — | IC50 | = | 32000.0 | nM | 4.50 |