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Assay Detail

CHEMBL2339942

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Binding
Inhibition of Staphylococcus aureus AgrC3
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Staphylococcus aureus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Attenuating Staphylococcus aureus virulence gene regulation: a medicinal chemistry perspective.
Gordon CP, Williams P, Chan WC.
J Med Chem (2013) 56 : 1389 -1404
PubMed 23294220 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 7.14 10.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2337558 1 10.00
CHEMBL2337555 1 9.52
CHEMBL2337554 1 8.52
CHEMBL1823954 1 8.40
CHEMBL2337557 1 8.00
CHEMBL1413443 1 6.89
CHEMBL1320442 1 6.80
CHEMBL2337556 1 6.62
CHEMBL1550371 1 6.60
CHEMBL1384476 1 6.14
CHEMBL1602820 1 6.01
CHEMBL1372899 1 6.01
CHEMBL1517237 1 5.90
CHEMBL1602023 1 5.88
CHEMBL2337550 1 5.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2337558 IC50 = 0.1 nM 10.00
CHEMBL2337555 IC50 = 0.3 nM 9.52
CHEMBL2337554 IC50 = 3.0 nM 8.52
CHEMBL1823954 IC50 = 4.0 nM 8.40
CHEMBL2337557 IC50 = 10.0 nM 8.00
CHEMBL1413443 IC50 = 130.0 nM 6.89
CHEMBL1320442 IC50 = 160.0 nM 6.80
CHEMBL2337556 IC50 = 240.0 nM 6.62
CHEMBL1550371 IC50 = 250.0 nM 6.60
CHEMBL1384476 IC50 = 720.0 nM 6.14
CHEMBL1602820 IC50 = 980.0 nM 6.01
CHEMBL1372899 IC50 = 980.0 nM 6.01
CHEMBL1517237 IC50 = 1260.0 nM 5.90
CHEMBL1602023 IC50 = 1310.0 nM 5.88
CHEMBL2337550 IC50 = 1510.0 nM 5.82