Assay Detail
Binding
CHEMBL2340475
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human recombinant CA13 at 37 degC and pH 7.0 by thermal shift assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
4-Substituted-2,3,5,6-tetrafluorobenzenesulfonamides as inhibitors of carbonic anhydrases I, II, VII, XII, and XIII.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 31 | 8.13 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2333406 | — | — | 1 | 9.66 |
| CHEMBL2333411 | — | — | 1 | 9.60 |
| CHEMBL2333403 | — | — | 1 | 9.40 |
| CHEMBL2333405 | — | — | 1 | 9.40 |
| CHEMBL2333407 | — | — | 1 | 9.40 |
| CHEMBL2333397 | — | — | 1 | 9.30 |
| CHEMBL2333402 | — | — | 1 | 9.00 |
| CHEMBL2333815 | — | — | 1 | 8.82 |
| CHEMBL2333418 | — | — | 1 | 8.77 |
| CHEMBL2333399 | — | — | 1 | 8.70 |
| CHEMBL2333415 | — | — | 1 | 8.66 |
| CHEMBL2333398 | — | — | 1 | 8.60 |
| CHEMBL2333410 | — | — | 1 | 8.60 |
| CHEMBL2333409 | — | — | 1 | 8.48 |
| CHEMBL2333816 | — | — | 1 | 8.48 |
| CHEMBL2333404 | — | — | 1 | 8.30 |
| CHEMBL2333419 | — | — | 1 | 8.17 |
| CHEMBL2333416 | — | — | 1 | 8.08 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.89 |
| CHEMBL2333814 | — | — | 1 | 7.85 |
| CHEMBL2333420 | — | — | 1 | 7.70 |
| CHEMBL2333412 | — | — | 1 | 7.70 |
| CHEMBL2333408 | — | — | 1 | 7.60 |
| CHEMBL2333417 | — | — | 1 | 7.54 |
| CHEMBL2333413 | — | — | 1 | 7.40 |
| CHEMBL2333400 | — | — | 1 | 7.30 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.30 |
| CHEMBL2333414 | — | — | 1 | 6.85 |
| CHEMBL2333401 | — | — | 1 | 6.54 |
| CHEMBL106848 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2333406 | — | Kd | = | 0.22 | nM | 9.66 |
| CHEMBL2333411 | — | Kd | = | 0.25 | nM | 9.60 |
| CHEMBL2333403 | — | Kd | = | 0.4 | nM | 9.40 |
| CHEMBL2333405 | — | Kd | = | 0.4 | nM | 9.40 |
| CHEMBL2333407 | — | Kd | = | 0.4 | nM | 9.40 |
| CHEMBL2333397 | — | Kd | = | 0.5 | nM | 9.30 |
| CHEMBL2333402 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL2333815 | — | Kd | = | 1.5 | nM | 8.82 |
| CHEMBL2333418 | — | Kd | = | 1.7 | nM | 8.77 |
| CHEMBL2333399 | — | Kd | = | 2.0 | nM | 8.70 |
| CHEMBL2333415 | — | Kd | = | 2.2 | nM | 8.66 |
| CHEMBL2333398 | — | Kd | = | 2.5 | nM | 8.60 |
| CHEMBL2333410 | — | Kd | = | 2.5 | nM | 8.60 |
| CHEMBL2333409 | — | Kd | = | 3.3 | nM | 8.48 |
| CHEMBL2333816 | — | Kd | = | 3.3 | nM | 8.48 |
| CHEMBL2333404 | — | Kd | = | 5.0 | nM | 8.30 |
| CHEMBL2333419 | — | Kd | = | 6.7 | nM | 8.17 |
| CHEMBL2333416 | — | Kd | = | 8.3 | nM | 8.08 |
| CHEMBL18 | ETHOXZOLAMIDE | Kd | = | 13.0 | nM | 7.89 |
| CHEMBL2333814 | — | Kd | = | 14.0 | nM | 7.85 |
| CHEMBL2333420 | — | Kd | = | 20.0 | nM | 7.70 |
| CHEMBL2333412 | — | Kd | = | 20.0 | nM | 7.70 |
| CHEMBL2333408 | — | Kd | = | 25.0 | nM | 7.60 |
| CHEMBL2333417 | — | Kd | = | 29.0 | nM | 7.54 |
| CHEMBL2333413 | — | Kd | = | 40.0 | nM | 7.40 |
| CHEMBL2333400 | — | Kd | = | 50.0 | nM | 7.30 |
| CHEMBL20 | ACETAZOLAMIDE | Kd | = | 50.0 | nM | 7.30 |
| CHEMBL2333414 | — | Kd | = | 140.0 | nM | 6.85 |
| CHEMBL2333401 | — | Kd | = | 290.0 | nM | 6.54 |
| CHEMBL106848 | — | Kd | = | 1400.0 | nM | 5.85 |
| CHEMBL27601 | BENZENESULFONAMIDE | Kd | = | 10000.0 | nM | 5.00 |