Assay Detail
Binding
CHEMBL2340587
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Displacement of [3H]-YM-09151-2 from human D4 dopamine receptor after 120 mins by liquid scintillation counting
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.15 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2333732 | — | — | 1 | 7.47 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.22 |
| CHEMBL597601 | — | — | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2333732 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL42 | CLOZAPINE | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL597601 | — | Ki | = | 170.0 | nM | 6.77 |