Assay Detail
Binding
CHEMBL2340873
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Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Spirocyclic compounds, potent CCR1 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.15 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2332935 | — | — | 1 | 8.70 |
| CHEMBL2332936 | — | — | 1 | 8.59 |
| CHEMBL2332942 | — | — | 1 | 7.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2332935 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2332936 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL2332942 | — | IC50 | = | 68.0 | nM | 7.17 |