Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL2340950

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human placental CYP19 using [1beta-3H]androstenedione as substrate by 3H2O-method
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Aromatase (CHEMBL1978)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Modulation of cytochromes P450 with xanthone-based molecules: from aromatase to aldosterone synthase and steroid 11β-hydroxylase inhibition.
Gobbi S, Hu Q, Negri M, Zimmer C, Belluti F, Rampa A, Hartmann RW, Bisi A.
J Med Chem (2013) 56 : 1723 -1729
PubMed 23363058 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 6.21 7.39

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL9298 FADROZOLE 2.0 1 7.39
CHEMBL2333336 1 6.77
CHEMBL2333335 1 6.58
CHEMBL2333328 1 6.52
CHEMBL2333331 1 6.40
CHEMBL2333327 1 6.34
CHEMBL2333326 1 6.32
CHEMBL2333334 1 6.25
CHEMBL2333333 1 6.24
CHEMBL2333332 1 6.08
CHEMBL78322 1 6.03
CHEMBL307160 1 6.01
CHEMBL2333329 1 5.96
CHEMBL2333330 1 5.71
CHEMBL442373 1 5.64
CHEMBL2333337 1 5.19
CHEMBL254328 ABIRATERONE 3.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL9298 FADROZOLE IC50 = 41.0 nM 7.39
CHEMBL2333336 IC50 = 170.0 nM 6.77
CHEMBL2333335 IC50 = 260.0 nM 6.58
CHEMBL2333328 IC50 = 300.0 nM 6.52
CHEMBL2333331 IC50 = 400.0 nM 6.40
CHEMBL2333327 IC50 = 460.0 nM 6.34
CHEMBL2333326 IC50 = 480.0 nM 6.32
CHEMBL2333334 IC50 = 565.0 nM 6.25
CHEMBL2333333 IC50 = 575.0 nM 6.24
CHEMBL2333332 IC50 = 837.0 nM 6.08
CHEMBL78322 IC50 = 940.0 nM 6.03
CHEMBL307160 IC50 = 970.0 nM 6.01
CHEMBL2333329 IC50 = 1100.0 nM 5.96
CHEMBL2333330 IC50 = 1973.0 nM 5.71
CHEMBL442373 IC50 = 2300.0 nM 5.64
CHEMBL2333337 IC50 = 6393.0 nM 5.19
CHEMBL254328 ABIRATERONE IC50 > 5000.0 nM -