Assay Detail
Binding
CHEMBL2340960
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC1 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfluidic lab-on-a-chip assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.69 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 8.40 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 6.84 |
| CHEMBL2333346 | — | — | 1 | 6.20 |
| CHEMBL16300 | BENZOHYDROXAMATE | — | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2018302 | TUBASTATIN A | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL2333346 | — | IC50 | = | 638.0 | nM | 6.20 |
| CHEMBL16300 | BENZOHYDROXAMATE | IC50 | = | 4730.0 | nM | 5.33 |