Assay Detail
Binding
CHEMBL2341204
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human PPARdelta expressed in HEK293 cells cotransfected with PPREx4-TK-luc assessed as activation of luciferase activity measured after 48 hrs by transactivation assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor delta (CHEMBL3979) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The discovery of novel isoflavone pan peroxisome proliferator-activated receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 4.68 | 4.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL573966 | — | — | 1 | 4.91 |
| CHEMBL575075 | — | — | 1 | 4.76 |
| CHEMBL486176 | PSEUDOBAPTOGENIN | — | 1 | 4.65 |
| CHEMBL583378 | — | — | 1 | 4.61 |
| CHEMBL264374 | BEZAFIBRATE | 3.0 | 1 | 4.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL573966 | — | EC50 | = | 12440.0 | nM | 4.91 |
| CHEMBL575075 | — | EC50 | = | 17170.0 | nM | 4.76 |
| CHEMBL486176 | PSEUDOBAPTOGENIN | EC50 | = | 22340.0 | nM | 4.65 |
| CHEMBL583378 | — | EC50 | = | 24390.0 | nM | 4.61 |
| CHEMBL264374 | BEZAFIBRATE | EC50 | = | 35740.0 | nM | 4.45 |