Assay Detail
Functional
CHEMBL2341528
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human S1P1 receptor transfected in CHO cells incubated for 10 to 15 mins prior to GTPgamma35S addition measured after 120 mins by GTPgamma35S binding assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 31 | 7.80 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2336086 | — | — | 1 | 9.52 |
| CHEMBL2336064 | — | — | 1 | 9.52 |
| CHEMBL2336069 | — | — | 1 | 9.40 |
| CHEMBL2336066 | — | — | 1 | 9.40 |
| CHEMBL2336071 | SIPONIMOD | 4.0 | 1 | 9.40 |
| CHEMBL2336065 | — | — | 1 | 9.22 |
| CHEMBL2336085 | — | — | 1 | 9.22 |
| CHEMBL2336068 | — | — | 1 | 9.15 |
| CHEMBL2336061 | — | — | 1 | 8.85 |
| CHEMBL2336070 | — | — | 1 | 8.80 |
| CHEMBL2336067 | — | — | 1 | 8.70 |
| CHEMBL2336062 | — | — | 1 | 8.66 |
| CHEMBL2336087 | — | — | 1 | 8.59 |
| CHEMBL2336079 | — | — | 1 | 8.10 |
| CHEMBL2336072 | — | — | 1 | 8.05 |
| CHEMBL2336080 | — | — | 1 | 7.96 |
| CHEMBL2336083 | — | — | 1 | 7.82 |
| CHEMBL2336082 | — | — | 1 | 7.80 |
| CHEMBL2336063 | — | — | 1 | 7.77 |
| CHEMBL2336084 | — | — | 1 | 7.75 |
| CHEMBL2336089 | — | — | 1 | 7.21 |
| CHEMBL2336081 | — | — | 1 | 7.03 |
| CHEMBL2336088 | — | — | 1 | 6.92 |
| CHEMBL2336073 | — | — | 1 | 6.68 |
| CHEMBL2336091 | — | — | 1 | 6.52 |
| CHEMBL2336074 | — | — | 1 | 6.19 |
| CHEMBL2336076 | — | — | 1 | 5.85 |
| CHEMBL2336075 | — | — | 1 | 5.82 |
| CHEMBL2336078 | — | — | 1 | 5.77 |
| CHEMBL2336077 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2336086 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL2336064 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL2336069 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL2336066 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL2336071 | SIPONIMOD | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL2336065 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL2336085 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL2336068 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL2336061 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL2336070 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL2336067 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2336062 | — | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL2336087 | — | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL2336079 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2336072 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2336080 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2336083 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2336082 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2336063 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2336084 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2336089 | — | EC50 | = | 61.0 | nM | 7.21 |
| CHEMBL2336081 | — | EC50 | = | 94.0 | nM | 7.03 |
| CHEMBL2336088 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2336073 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL2336091 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2336074 | — | EC50 | = | 640.0 | nM | 6.19 |
| CHEMBL2336076 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2336075 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2336078 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL2336077 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2336090 | — | EC50 | = | 10000.0 | nM | 5.00 |