Assay Detail
Binding
CHEMBL2341919
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist at human PPARgamma LBD expressed in human HEK293 cells cotransfected with GAL4-Luc assessed as transcriptional activation by luciferase reporter gene assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structural characterization of amorfrutins bound to the peroxisome proliferator-activated receptor γ.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.99 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 1 | 8.40 |
| CHEMBL2337127 | — | — | 1 | 7.30 |
| CHEMBL491820 | AMORFRUTIN A | — | 1 | 6.34 |
| CHEMBL2337126 | — | — | 1 | 5.92 |
| CHEMBL38508 | — | — | 1 | - |
| CHEMBL21241 | GW7647 | — | 1 | - |
| CHEMBL1204498 | — | — | 1 | - |
| CHEMBL2337128 | — | — | 1 | - |
| CHEMBL370152 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL121 | ROSIGLITAZONE | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2337127 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL491820 | AMORFRUTIN A | EC50 | = | 458.0 | nM | 6.34 |
| CHEMBL2337126 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL38508 | — | EC50 | - | — | - | |
| CHEMBL21241 | GW7647 | EC50 | - | — | - | |
| CHEMBL1204498 | — | EC50 | - | — | - | |
| CHEMBL2337128 | — | EC50 | - | — | - | |
| CHEMBL370152 | — | EC50 | - | — | - |