Assay Detail
Binding
CHEMBL2341920
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Binding affinity to human PPARgamma (unknown origin) by competitive TR-FRET assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structural characterization of amorfrutins bound to the peroxisome proliferator-activated receptor γ.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 7.22 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 1 | 8.15 |
| CHEMBL2337127 | — | — | 1 | 7.72 |
| CHEMBL370152 | — | — | 1 | 7.54 |
| CHEMBL21241 | GW7647 | — | 1 | 6.75 |
| CHEMBL491820 | AMORFRUTIN A | — | 1 | 6.63 |
| CHEMBL2337126 | — | — | 1 | 6.54 |
| CHEMBL38508 | — | — | 1 | - |
| CHEMBL1204498 | — | — | 1 | - |
| CHEMBL2337128 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL121 | ROSIGLITAZONE | Kd | = | 7.0 | nM | 8.15 |
| CHEMBL2337127 | — | Kd | = | 19.0 | nM | 7.72 |
| CHEMBL370152 | — | Kd | = | 29.0 | nM | 7.54 |
| CHEMBL21241 | GW7647 | Kd | = | 180.0 | nM | 6.75 |
| CHEMBL491820 | AMORFRUTIN A | Kd | = | 236.0 | nM | 6.63 |
| CHEMBL2337126 | — | Kd | = | 287.0 | nM | 6.54 |
| CHEMBL38508 | — | Kd | - | — | - | |
| CHEMBL1204498 | — | Kd | - | — | - | |
| CHEMBL2337128 | — | Kd | - | — | - |