Assay Detail
Functional
CHEMBL2342019
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Cytotoxicity against human NCI-H23 cell assessed as inhibition of colony formation after 10 days by clonogenic assay
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H23 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and optimization of 3-(2-(Pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as novel selective and orally bioavailable discoidin domain receptor 1 (DDR1) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 2 | - | - |
| IC50 | 2 | 5.87 | 6.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2336015 | — | — | 2 | 6.25 |
| CHEMBL2336017 | — | — | 2 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2336015 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL2336017 | — | IC50 | = | 3290.0 | nM | 5.48 |
| CHEMBL2336017 | — | Inhibition | - | % | - | |
| CHEMBL2336015 | — | Inhibition | - | % | - |