Assay Detail
Binding
CHEMBL2343130
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Inhibition of rat full length DAAO overexpressed in HEK293 cells after 30 mins by plate reader analysis
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
4-Hydroxypyridazin-3(2H)-one derivatives as novel D-amino acid oxidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.88 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2338798 | — | — | 1 | 8.66 |
| CHEMBL2338800 | — | — | 1 | 8.66 |
| CHEMBL2338790 | — | — | 1 | 8.62 |
| CHEMBL2338797 | — | — | 1 | 8.59 |
| CHEMBL2338787 | — | — | 1 | 8.51 |
| CHEMBL2338802 | — | — | 1 | 8.42 |
| CHEMBL2338786 | — | — | 1 | 8.34 |
| CHEMBL2338795 | — | — | 1 | 8.31 |
| CHEMBL2338801 | LUVADAXISTAT | 2.0 | 1 | 8.30 |
| CHEMBL2338799 | — | — | 1 | 8.25 |
| CHEMBL2338794 | — | — | 1 | 8.19 |
| CHEMBL2338789 | — | — | 1 | 8.09 |
| CHEMBL2338803 | — | — | 1 | 7.80 |
| CHEMBL2338805 | — | — | 1 | 7.72 |
| CHEMBL2338796 | — | — | 1 | 7.39 |
| CHEMBL2338791 | — | — | 1 | 6.33 |
| CHEMBL2338788 | — | — | 1 | 5.92 |
| CHEMBL2338804 | — | — | 1 | 5.72 |
| CHEMBL2338793 | — | — | 1 | - |
| CHEMBL2338792 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2338798 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL2338800 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL2338790 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL2338797 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL2338787 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL2338802 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL2338786 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL2338795 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL2338801 | LUVADAXISTAT | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2338799 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL2338794 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL2338789 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL2338803 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2338805 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2338796 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL2338791 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL2338788 | — | IC50 | = | 1217.0 | nM | 5.92 |
| CHEMBL2338804 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL2338793 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2338792 | — | IC50 | > | 1000.0 | nM | - |