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Assay Detail

CHEMBL2343271

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and biological evaluation of 2-(alkoxycarbonyl)-3-anilinobenzo[b]thiophenes and thieno[2,3-b]pyridines as new potent anticancer agents.
Romagnoli R, Baraldi PG, Kimatrai Salvador M, Preti D, Aghazadeh Tabrizi M, Bassetto M, Brancale A, Hamel E, Castagliuolo I, Bortolozzi R, Basso G, Viola G.
J Med Chem (2013) 56 : 2606 -2618
PubMed 23445496 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 6.76 9.28

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2332030 1 9.28
CHEMBL2332025 1 9.15
CHEMBL2332022 1 8.92
CHEMBL2332026 1 8.25
CHEMBL2332023 1 8.05
CHEMBL2332027 1 7.02
CHEMBL67 COMBRETASTATIN A4 -1.0 1 6.43
CHEMBL2332021 1 6.27
CHEMBL2332017 1 6.10
CHEMBL2332028 1 5.58
CHEMBL2332020 1 5.38
CHEMBL2332024 1 5.34
CHEMBL2332029 1 5.28
CHEMBL2332018 1 5.19
CHEMBL2332019 1 5.09

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2332030 IC50 = 0.53 nM 9.28
CHEMBL2332025 IC50 = 0.7 nM 9.15
CHEMBL2332022 IC50 = 1.2 nM 8.92
CHEMBL2332026 IC50 = 5.6 nM 8.25
CHEMBL2332023 IC50 = 9.0 nM 8.05
CHEMBL2332027 IC50 = 95.0 nM 7.02
CHEMBL67 COMBRETASTATIN A4 IC50 = 370.0 nM 6.43
CHEMBL2332021 IC50 = 540.0 nM 6.27
CHEMBL2332017 IC50 = 795.0 nM 6.10
CHEMBL2332028 IC50 = 2644.0 nM 5.58
CHEMBL2332020 IC50 = 4153.0 nM 5.38
CHEMBL2332024 IC50 = 4548.0 nM 5.34
CHEMBL2332029 IC50 = 5275.0 nM 5.28
CHEMBL2332018 IC50 = 6391.0 nM 5.19
CHEMBL2332019 IC50 = 8192.0 nM 5.09