Assay Detail
Binding
CHEMBL2343279
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]spiperone from dopamine D2 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 34 | 7.11 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267930 | SPIPERONE | 2.0 | 1 | 8.92 |
| CHEMBL487387 | STEPHOLIDINE | — | 1 | 7.96 |
| CHEMBL2334893 | — | — | 1 | 7.50 |
| CHEMBL2334891 | — | — | 1 | 7.04 |
| CHEMBL2334892 | — | — | 1 | 6.98 |
| CHEMBL320397 | — | — | 1 | 6.95 |
| CHEMBL490533 | CANADINE | — | 1 | 6.92 |
| CHEMBL1457510 | — | — | 1 | 6.84 |
| CHEMBL2057456 | — | — | 1 | 6.83 |
| CHEMBL2057457 | — | — | 1 | 6.79 |
| CHEMBL1235966 | SCOULERINE | — | 1 | 6.67 |
| CHEMBL448891 | — | — | 1 | 6.52 |
| CHEMBL2057453 | — | — | 1 | 6.46 |
| CHEMBL2334888 | — | — | 1 | - |
| CHEMBL2334886 | — | — | 1 | - |
| CHEMBL2334885 | — | — | 1 | - |
| CHEMBL2314733 | — | — | 1 | - |
| CHEMBL2334884 | — | — | 1 | - |
| CHEMBL522746 | TETRAHYDROPALMATRUBINE | — | 1 | - |
| CHEMBL2334889 | — | — | 1 | - |
| CHEMBL476501 | — | — | 1 | - |
| CHEMBL2334890 | — | — | 1 | - |
| CHEMBL1395394 | — | — | 1 | - |
| CHEMBL2057455 | — | — | 1 | - |
| CHEMBL13668 | — | — | 1 | - |
| CHEMBL2334882 | — | — | 1 | - |
| CHEMBL2334881 | — | — | 1 | - |
| CHEMBL2334880 | — | — | 1 | - |
| CHEMBL2334883 | — | — | 1 | - |
| CHEMBL2334894 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267930 | SPIPERONE | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL487387 | STEPHOLIDINE | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL2334893 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL2334891 | — | Ki | = | 91.0 | nM | 7.04 |
| CHEMBL2334892 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL320397 | — | Ki | = | 113.0 | nM | 6.95 |
| CHEMBL490533 | CANADINE | Ki | = | 119.0 | nM | 6.92 |
| CHEMBL1457510 | — | Ki | = | 145.0 | nM | 6.84 |
| CHEMBL2057456 | — | Ki | = | 147.0 | nM | 6.83 |
| CHEMBL2057457 | — | Ki | = | 161.0 | nM | 6.79 |
| CHEMBL1235966 | SCOULERINE | Ki | = | 214.0 | nM | 6.67 |
| CHEMBL448891 | — | Ki | = | 305.0 | nM | 6.52 |
| CHEMBL2057453 | — | Ki | = | 347.0 | nM | 6.46 |
| CHEMBL2314732 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL487182 | TETRAHYDROPALMATINE | Ki | > | 5000.0 | nM | - |
| CHEMBL39 | SEROTONIN | Ki | - | — | - | |
| CHEMBL2334887 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL2334888 | — | Ki | - | — | - | |
| CHEMBL2334886 | — | Ki | - | — | - | |
| CHEMBL2334885 | — | Ki | - | — | - | |
| CHEMBL2314733 | — | Ki | - | — | - | |
| CHEMBL2334884 | — | Ki | - | — | - | |
| CHEMBL522746 | TETRAHYDROPALMATRUBINE | Ki | - | — | - | |
| CHEMBL2334889 | — | Ki | - | — | - | |
| CHEMBL476501 | — | Ki | - | — | - | |
| CHEMBL2334890 | — | Ki | - | — | - | |
| CHEMBL1395394 | — | Ki | - | — | - | |
| CHEMBL2057455 | — | Ki | - | — | - | |
| CHEMBL13668 | — | Ki | - | — | - | |
| CHEMBL2334882 | — | Ki | - | — | - | |
| CHEMBL2334881 | — | Ki | - | — | - | |
| CHEMBL2334880 | — | Ki | - | — | - | |
| CHEMBL2334883 | — | Ki | - | — | - | |
| CHEMBL2334894 | — | Ki | - | — | - |