Assay Detail
Functional
CHEMBL2343458
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CYtotoxicity against ER-negative human MDA-MB-231 cells by MTS assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Fragment-based drug design and identification of HJC0123, a novel orally bioavailable STAT3 inhibitor for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.63 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2335104 | — | — | 1 | 6.54 |
| CHEMBL2335098 | — | — | 1 | 6.35 |
| CHEMBL1448 | NICLOSAMIDE | 4.0 | 1 | 6.10 |
| CHEMBL2335107 | — | — | 1 | 5.82 |
| CHEMBL2335108 | — | — | 1 | 5.79 |
| CHEMBL2335101 | — | — | 1 | 5.73 |
| CHEMBL2335102 | — | — | 1 | 5.21 |
| CHEMBL2335106 | — | — | 1 | 5.05 |
| CHEMBL2335105 | — | — | 1 | 4.07 |
| CHEMBL2335100 | — | — | 1 | - |
| CHEMBL2335099 | — | — | 1 | - |
| CHEMBL2335109 | — | — | 1 | - |
| CHEMBL2335103 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2335104 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL2335098 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL1448 | NICLOSAMIDE | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL2335107 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL2335108 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL2335101 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL2335102 | — | IC50 | = | 6210.0 | nM | 5.21 |
| CHEMBL2335106 | — | IC50 | = | 8880.0 | nM | 5.05 |
| CHEMBL2335105 | — | IC50 | = | 86000.0 | nM | 4.07 |
| CHEMBL2335100 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2335099 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2335109 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2335103 | — | IC50 | > | 10000.0 | nM | - |