Assay Detail
Functional
CHEMBL2343476
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against erythrocytic stage of chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 assessed as inhibition of [3H]-hypoxanthine incorporation incubated for 48 hrs prior to [3H]-hypoxanthine addition measured after 24 hrs by liquid scintillation counting
63
Total Activities
63
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and structure-activity relationships of pyrrolone antimalarials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 63 | 6.49 | 10.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 10.02 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 8.22 |
| CHEMBL2335632 | — | — | 1 | 8.15 |
| CHEMBL2335594 | — | — | 1 | 8.10 |
| CHEMBL600928 | — | — | 1 | 8.05 |
| CHEMBL2335990 | — | — | 1 | 7.72 |
| CHEMBL2335611 | — | — | 1 | 7.70 |
| CHEMBL2335991 | — | — | 1 | 7.68 |
| CHEMBL2335592 | — | — | 1 | 7.58 |
| CHEMBL2335989 | — | — | 1 | 7.57 |
| CHEMBL2335595 | — | — | 1 | 7.54 |
| CHEMBL2335987 | — | — | 1 | 7.50 |
| CHEMBL2335986 | — | — | 1 | 7.42 |
| CHEMBL2335597 | — | — | 1 | 7.35 |
| CHEMBL2335629 | — | — | 1 | 7.30 |
| CHEMBL2335591 | — | — | 1 | 7.20 |
| CHEMBL2335988 | — | — | 1 | 7.19 |
| CHEMBL1602168 | — | — | 1 | 7.19 |
| CHEMBL2335600 | — | — | 1 | 7.15 |
| CHEMBL2335607 | — | — | 1 | 7.11 |
| CHEMBL2335606 | — | — | 1 | 7.05 |
| CHEMBL2335993 | — | — | 1 | 7.02 |
| CHEMBL2335604 | — | — | 1 | 6.92 |
| CHEMBL2335590 | — | — | 1 | 6.89 |
| CHEMBL2335602 | — | — | 1 | 6.72 |
| CHEMBL2335609 | — | — | 1 | 6.72 |
| CHEMBL2335622 | — | — | 1 | 6.57 |
| CHEMBL2335618 | — | — | 1 | 6.54 |
| CHEMBL2335628 | — | — | 1 | 6.52 |
| CHEMBL2335605 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | EC50 | = | 0.095 | nM | 10.02 |
| CHEMBL269671 | ARTEMISININ | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2335632 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2335594 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL600928 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2335990 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2335611 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2335991 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2335592 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL2335989 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2335595 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2335987 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2335986 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL2335597 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL2335629 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2335591 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL2335988 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL1602168 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL2335600 | — | EC50 | = | 71.0 | nM | 7.15 |
| CHEMBL2335607 | — | EC50 | = | 77.0 | nM | 7.11 |
| CHEMBL2335606 | — | EC50 | = | 89.0 | nM | 7.05 |
| CHEMBL2335993 | — | EC50 | = | 95.0 | nM | 7.02 |
| CHEMBL2335604 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2335590 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2335609 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2335602 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2335622 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL2335618 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL2335628 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2335605 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2335631 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL2335610 | — | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL2335608 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL2335620 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL2335984 | — | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL2335633 | — | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL2335171 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL2335613 | — | EC50 | = | 820.0 | nM | 6.09 |
| CHEMBL2335170 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2335985 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2335589 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2335983 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2335630 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2335612 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2335619 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2335598 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2335603 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL2335168 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL2335623 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL2335616 | — | EC50 | = | 2100.0 | nM | 5.68 |