Assay Detail
Binding
CHEMBL2343549
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human alpha3beta4 nAChR expressed in CHO cells assessed as inhibition of calcium influx by calcium-4 based FLIPR analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha3/beta4 (CHEMBL1907594) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Pharmacological properties and predicted binding mode of arylmethylene quinuclidine-like derivatives at the α3β4 nicotinic acetylcholine receptor (nAChR).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.78 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2332278 | — | — | 1 | 7.10 |
| CHEMBL2332280 | — | — | 1 | 7.00 |
| CHEMBL2332279 | — | — | 1 | 6.70 |
| CHEMBL478358 | — | — | 1 | 5.22 |
| CHEMBL2179959 | — | — | 1 | 5.00 |
| CHEMBL2332276 | — | — | 1 | 4.82 |
| CHEMBL2332277 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2332278 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2332280 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2332279 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL478358 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL2179959 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2332276 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL2332277 | — | IC50 | = | 23000.0 | nM | 4.64 |