Assay Detail
Binding
CHEMBL2343995
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Inhibition of PI3K in human BT20 cells assessed as inhibition of AKT Ser473 phosphorylation
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BT-20 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04979064 through Structure-Based Drug Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.66 | 8.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2331664 | — | — | 1 | 8.04 |
| CHEMBL2331659 | — | — | 1 | 8.02 |
| CHEMBL2331666 | — | — | 1 | 7.96 |
| CHEMBL2331668 | — | — | 1 | 7.94 |
| CHEMBL2331658 | — | — | 1 | 7.81 |
| CHEMBL2331661 | — | — | 1 | 7.78 |
| CHEMBL2331663 | — | — | 1 | 7.76 |
| CHEMBL2331665 | — | — | 1 | 7.65 |
| CHEMBL2331669 | — | — | 1 | 7.55 |
| CHEMBL2331667 | — | — | 1 | 7.50 |
| CHEMBL2331662 | — | — | 1 | 7.50 |
| CHEMBL2331660 | — | — | 1 | 7.24 |
| CHEMBL2331657 | — | — | 1 | 6.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2331664 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL2331659 | — | IC50 | = | 9.52 | nM | 8.02 |
| CHEMBL2331666 | — | IC50 | = | 11.1 | nM | 7.96 |
| CHEMBL2331668 | — | IC50 | = | 11.6 | nM | 7.94 |
| CHEMBL2331658 | — | IC50 | = | 15.4 | nM | 7.81 |
| CHEMBL2331661 | — | IC50 | = | 16.8 | nM | 7.78 |
| CHEMBL2331663 | — | IC50 | = | 17.3 | nM | 7.76 |
| CHEMBL2331665 | — | IC50 | = | 22.5 | nM | 7.65 |
| CHEMBL2331669 | — | IC50 | = | 28.3 | nM | 7.55 |
| CHEMBL2331667 | — | IC50 | = | 31.5 | nM | 7.50 |
| CHEMBL2331662 | — | IC50 | = | 31.6 | nM | 7.50 |
| CHEMBL2331660 | — | IC50 | = | 57.9 | nM | 7.24 |
| CHEMBL2331657 | — | IC50 | = | 144.0 | nM | 6.84 |