Assay Detail
Binding
CHEMBL2344100
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Inhibition of recombinant human carbonic anhydrase 9 after 15 mins by stopped flow CO2 hydration assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of heterocyclic substituted benzenesulfonamides as novel carbonic anhydrase IX inhibitors and their structure activity relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.77 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 9.60 |
| CHEMBL2336905 | — | — | 1 | 9.32 |
| CHEMBL2336906 | — | — | 1 | 8.48 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.11 |
| CHEMBL2336904 | — | — | 1 | 7.73 |
| CHEMBL2336902 | — | — | 1 | 7.55 |
| CHEMBL2336903 | — | — | 1 | 7.54 |
| CHEMBL2336899 | — | — | 1 | 6.16 |
| CHEMBL2336896 | — | — | 1 | 5.41 |
| CHEMBL2336901 | — | — | 1 | - |
| CHEMBL2336900 | — | — | 1 | - |
| CHEMBL2336898 | — | — | 1 | - |
| CHEMBL2336897 | — | — | 1 | - |
| CHEMBL2336895 | — | — | 1 | - |
| CHEMBL2336894 | — | — | 1 | - |
| CHEMBL2313213 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19 | METHAZOLAMIDE | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL2336905 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL2336906 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL20 | ACETAZOLAMIDE | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL2336904 | — | IC50 | = | 18.5 | nM | 7.73 |
| CHEMBL2336902 | — | IC50 | = | 28.3 | nM | 7.55 |
| CHEMBL2336903 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2336899 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL2336896 | — | IC50 | = | 3930.0 | nM | 5.41 |
| CHEMBL2336901 | — | IC50 | > | 690.0 | nM | - |
| CHEMBL2336900 | — | IC50 | > | 690.0 | nM | - |
| CHEMBL2336898 | — | IC50 | > | 690.0 | nM | - |
| CHEMBL2336897 | — | IC50 | > | 690.0 | nM | - |
| CHEMBL2336895 | — | IC50 | > | 3900.0 | nM | - |
| CHEMBL2336894 | — | IC50 | > | 3900.0 | nM | - |
| CHEMBL2313213 | — | IC50 | > | 3900.0 | nM | - |