Assay Detail
Binding
CHEMBL2344115
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant NEK1 (unknown origin) by FRET-based Z'-LYTE assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase Nek1 (CHEMBL5855) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Monocarbonyl curcumin analogues: heterocyclic pleiotropic kinase inhibitors that mediate anticancer properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.81 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL574646 | — | — | 1 | 6.30 |
| CHEMBL2338333 | — | — | 1 | 5.46 |
| CHEMBL2036343 | — | — | 1 | 4.85 |
| CHEMBL379849 | — | — | 1 | 4.11 |
| CHEMBL2338335 | — | — | 1 | 4.08 |
| CHEMBL2338334 | — | — | 1 | 4.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL574646 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2338333 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL2036343 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL379849 | — | IC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL2338335 | — | IC50 | = | 83000.0 | nM | 4.08 |
| CHEMBL2338334 | — | IC50 | = | 83000.0 | nM | 4.08 |